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Blood samples for antibody testing were obtained from mother and infant within 24 hours of delivery, and from infants at 16 weeks. All infants received immunizations according to national protocol including: The ratio of infant to maternal antibody levels at birth was used as a proxy for placental transfer.
Antibody response following vaccination was measured in infants at 16 weeks. In multiple regression analysis, HIV exposure was associated with reduced antibody titres to all antigens. All HIV-infected women chose exclusive formula feeding; HIV-uninfected women were counseled to exclusively breastfeed.
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Conclusions This study shows that HIV exposed uninfected infants compared to unexposed infants have lower specific antibody levels at birth, and a smaller proportion have Ab levels that are protective. Both HIV positive and negative women were included if they had delivered an infant within the last 24 hours, were over 18 years old, were healthy, and did not have TB.